For years, I hunted hogs with my Smith 25-5, 6 inch barrel. I used a 250 gr Speer LSWC over 9 grains of Unique. Worked well, never lost a piggy.
I am working on a new load for my Bisley Vaquero, with the 4 5/8 barrel. the bullet I am trying is the Hornady 250 HP/XTP, and I am working with 2400, Lil Gun, and BlueDot.