The Single Sixes are exellent revolvers.
You can definately carry it with all chambers loaded. The transfer bar system allows this with perfect safety.
Unless you shoot the hyper velocity 22 magnum ammo, you likely won't notice a huge difference in terminal performance. Now, if you load it up with CCI TNT HPs(my favorite), or Winchester supremes, or a few of the other hot loads you'll get a lot more performance on bigger critters like foxes, groundhogs, or coons.