Can you, yes. Do I recommend it, no.
Several folks on here seem to like the 180s and 200s in .44 mag for deer but I'm not one of them. I shot one many many long years ago with a 180 pre XTP Hornady bullet. Killed it fine but bullet failed to exit. I like big exit holes so I switched immediately to 240 grain bullets and have killed a lot of deer with the .44 mag since and never yet had one fail to exit.
I'd not depend on it to break bones and get on thru personally. Shot into the lung/heart region from broadside or slightly quartering away angles it will do massive damage to the vitals and kill quickly. But is unlikely to exit and thus the blood trail will be sparse if you don't happen to drop it in sight of you. Don't expect it to penetrate deeply from severe angles to get the job done as a heavier bullet will.