The hunting rifle I carried for 25 years, was a Ruger M-77, in .338 win mag. It has a 1.75X5 Red Field. I have taken Caribou, and Moose consistently. While most shots are around 80 yards, a few have been farther, one Moose out to 500yards.
I now carry nothing but single shots. As you said the lighter, and shorter, gun is much easier to handle and carry. I now carry one of three guns, depending on the time of year. A TCR in .338 w/3X9X50, a Handi in .35Whelen w/1.25X4X30, and the one I carry 75% of the time a Handi in 30-06 w/6X24X40. The 30-06 had a Shepard scope and will again wear one as soon as I can afford to replace the stolen one. The reason for the more power on the 30-06, is I use it to shoot wolves during the winter. Often times 4 and 5 hundred yards is as close as we can get. I use the snow machine seat as a rest. Frequently a wolf will hide behind a bush, and not give a good shot. Good optics are essential to see at that range, and to find any openings in the brush.
For practice I shoot 4" clay targets, at 300 yards. I don't use paper except to sight in. The .338, and 30-06 are sighted in for 300 yards. The .35 Whelen is sighted in for 150 yards.