I shoot 450 to 510 grain bullets and have found the 1 in 18 twist ( Green Mountain barrel) to be fine, but at the lower velocities it might be advantages to look at a slower twist of 1 in 20 or 24, check with your barrel maker or give Dave, at Lone Star Rifle a call, he is a fan and authority on the 50/90.
life is no joke but funny things happen
jon