No not in a long time--my 240 Sierra 240 JHC/4198 loads--which are very safe, are identical to yours! My 300gr Sierra's 42.5 of 4198. Both are extremely accurate. Rem Factory 265's actually seem hotter than either. I want to get a 15" 444 for my Encore. The 300gr whistled right through a big Buck last year, I don't think it expanded much, but there was rib bones and lung all over the leaves. He still went about 150yds, but was real easy to trail. Big hole in, only a little bigger exit, but the lung tissue was hanging out the hole! The shot was about half way back through the rib cage. Believe it or not, The deer I shot in the lungs with my Encore 243 and a 100gr Nosler Balistic tip dropped deer quicker. BUT, the blood trail wasn't nearly as impressive. I'm still searching for another Elk Hand-gun. I've used a TC 35 Remington and a TC 375JDJ and both worked great. I want to try my 45-70, 444 Marlin, 30'06, and my 358JDJ--I just don't have enough licenses! My #1 '06 is shooting sub-1" groups with the 180gr Nosler bullets and flies between 2450 and 2475 FPS, My #2 30'06 M/T will not shoot the 180 gr load at all. 150's and 165's shoot into sub-1" holes. I can't them out. The barrels are definitely different cuz the 150's are only going at a shade over 2500FPS! It is nice to have 2 barrels that shoot different loads. Less changing of scope settings.