I'm shooting it in a 26" Encore barrel. I've only shot cast in it at present (70 rounds) but find it to have plenty of accuracy potential. My alloy is currently on the soft side for the 1-12 twist, so I'm playing around with that. I'm considering either the Hornady 220 or the Barnes 255 Original for jacketed loads, as I got this for a heavy deer thumper, and figure anything else in 375 is going to be so heavily jacketed that the bullets will only pinhole deer, and even on heavy game the heavy bullets will be at the lower end of impact velocity requirements.
Performance wise, from a rifle one should get equal to and a bit better than 358 Winchester performance. Better as the bullet weight gets heavier. Will it do 35 Whelen? I doubt it, but it would be close. The most comparable cartridge to the 375 JDJ would be the old 9.3x57. JD says to add 10% to pistol velocities for carbine/rifle barrels.