I, myself have been kicking around the same dilema on a caliber to round out my midrange battery. I've decided on the Ruger magnum rifle and have been trying to decide between 416 & 458 Lott. For a long time a favored the 416, but have recently finallized on the 458 Lott for these reasons: Bullet selection is so great, from 250-600 grainers. I'm thinking to make two types of loads, one a flat-shooting spire piont type in 300-400 grains for my plains type game and the other a 450-500 grainer for the heavies. I would mount two seperate scopes, probably the Leupold 1.5-5 VX-111 for the heavies & maybe a 2-7 size for the plains rounds, both in Talley QD rings. Trajectories on the lighter bullet would be fine to 250-300 yards. Plus, the straight wall cases are so easy to load and last forever. Then if I need a short-range stopper, just remove the scope & go to the integral express sights, plus w/ 2 scopes you have a back up if one fails. The reason I consider this my mid-range round is I have a 300 Win for the light stuff & a 600 JDJ for heavy use. This would give me a good, flexible, all around rifle in the middle.