I got to get to the range the other day with my 12" .44mag Encore.
The load that gave me 1" groups at 50 yds from my 7.5" SRH at 1260fps gave me 1410fps and .75" grouping in the Encore. Powder is AA#9 bullet was a LBT 280g WFNGC. H110 would probably give 1500 without much fuss.
Encores are somewhat big and heafty, but it helps stabilize my aim, plus with a light load of AA#5 for about 1250 with the same bullet, and most game inside 100yds should prove to be a clean harvest.
Ever see that guy on T.V. that hits small 6" balloons at 200 yds with a big 454 revolver? Best part was when he pulled out his .38 snubbie and did the same thing.