I wish I had good advice for you, but here are some thoughts:
I have a .308 I use in the bogs and spruce thickets in Northwestern Maine. I want that rifle to give me a second shot quickly if I should need it knowing that I probably won't have time at those ranges. I want the bullet to be accurate and "hold together" for the 20 yard shot. In addition, when I step to the edge of a clear-cut or look 200 yards down a two-track and see horns, I want a bullet that will group into a 3-4 inch circle as that may be the size of the window I've got in the brush out there.
Graybeard's advice is probably the best with the additional consideration others have offered about how well the bullet will hold together at close ranges, in my opinion ( you did want many opinions?).
I guess I also try to remember that my cousin's boy, who is ten, shot his deer last year here in the Vermont hardwoods with a .223 at 50 yards - right through the boiler room. It ran less than 30 yards. What I mean is, any bullet that gets through to the lungs will anchor a deer. For Maine I am thinking of changing to 180 grain bullets loaded for a muzzle velocity of @2400 only because I'm never sure I'll get a simple standing lung shot in the tight woods.
BTW- that .308 rifle is a Savage99F.
Now, if I'm going to be in a stand at the edge of a Maine clearcut, I'll carry my .270 or 30-06. In the 06 I'll use 165 grain bullets loaded a little hot so they'll reach - some of those clear-cuts are a half a mile wide (not that I'll shoot quite THAT far). From experience I know the 165s are accurate enough in that 03-A3 and that they will hit hard by the time they arrive at @ 2200 -2600 fps.
I guess I'm telling you that there is no perfect answer - you just consider all the possibilities, weigh their likelihood of ocurring, and then you make your decision based upon what you decide is most likely to happen.
Remember to spend some time practicing, too.
Best Wishes,
Harold