Between myself & my brother & a friend, we have taken a bunch (whole bunch) of White Tail, Mule Deer & Antelope from 300-375 yards. I took one Antelope last fall at a little over 400 yards. I have no qualms about shooting a little further under the right conditions with my present 25-06AI load & rifle I use. None of these had to be chased, & I would rather not do that. However, I have had to chase a couple of Deer that I shot at close range with other rounds, due to hitting a limb & poor placement, not because of the round.
Oh yea, one groundhog at a little over 700 & a lot of Varmits closer.
I hope this doesn't turn into a silly ethics lecture & it shouldn't, the question was asked & I answered.