Sorry I was gone awhile unexpectedly. While catching up, this post caught my attention.
Hmm, where to start. Well I agree and disagree here. While a 20-220 would be inefficient, there are other in use equally so. The 7STW and 30-378 come to mind, and the 6-.284 isn't far off. But this is definately in the realm for a 28"-30" barrel in my mind. If you have the time and money, it is your choice. Personally, I agree with the accuracy part. For the most part, more speed is desired for longer range work. Small calibers and lighter bullets can be fickle in a mild breeze at long range. More speed isn't always the answer. Accuracy is or should always be #1. Also, the more inefficient bore , generally speaking, need to be cleaned more often to maintain peak accuracy. But one never knows untill one tries either.
As far as load data for such a round. Well, there are a couple excellent computer programs that brace that issue. With those, caution still needs to be used as with any other reloading data. The critical part is "pluging in" the correct information to start with.
Your proposed round will be burning quite abit of powder in relationship to bore diameter. But if you don't get it too hot, life of the barrel won't be any shorter than those mentioned above. Just don't shoot so fast between shots.
Dave