You start with factory equivalent loads, that's what the sights are (supposedly) set for. Standard bullet weight, standard velocity for the caliber. Most shoot close to POA. I never have adjusted adjustable sights more than the once it takes after taking the gun out of the box, so what's the difference? A Ruger, particularly, has the same large rear sight notch as is on the Blackhawk, or close enough for folk music, and many target sights are not that great either.