You just have to experiment and find what your rifle likes.I,myself,would much prefer a hornady iterlock or interbond bullet over the siearra bullet for hunting as I feel the hornady offers better constuction for inpact velosities both,up close and out far where as the siearra is to thinly constructed for up close shots.The siearras are a very accurate bullet,as I have discovered in all my rifles but then,so have the hornadys.I care not,if there is a .040 difference because of a bullet uniformity problem.I have done a lot of experimenting over the 30 plus years of reloading to truthfully say that I may only see a very slim difference,if any at all in the accuracy of say a bullet just touching the lands or .040 off the lands.Actually,I prefer a little bullet jump to the lands for stabilization.We can all reload clone like cartridges for our day at the range but least we do everything a like at the bench,such as breathing,positioning the rifle the same way,holding the rifle the same,sitting the same,it's all going to be for not.You'll have more of a difference in POI ,then if a bullet's dims are a little off or you col is different from one cartridge to another.Pick the bullet with the best constuction for terminal performance on game.You have no bench in the field and it matters not if your .500 grouping bullet hits where it is suppose to then blows up on impact.I'd rather be a half inch off and have a bullet do it's job.Remember,we are not trying to place three shots inside an inch on an elk,just one well place bullet to cleanly take that animal.