I bought my GP 100, 6" barrel, in 2003 and have been very pleased with the accuracy. The rear site when it was first fired were off a few inches, adjusted accordingly. The European guns I have purchased are always sited to go, right out of the box, so I was a little spoiled from that.
Used some handloads from a fellow shooter, man that revolver sure can put em' in tight. Factory loads shoot good too. I have heard of people having trigger jobs done on their Rugers, and this revolver as well as my Single-six in .22 RF have not had the triggers worked on. The GP 100 trigger feels abit heavy, but at this time I shoot it with the original trigger from the factory, not sure if I will change that as it does the job.
As far as appearences go compared to Smith and Wesson, I like the looks of the GP 100. Some shooters think they are clunky, but that heavier appearence does demonstrate strength.