When I first started re-loading, I was concerned about using H110 due to the warnings about not downloading it.
What I have found is that H 110 is an outstanding powder for full patch loads, it is predictable and linear when used within loading guidelines, and produces consistant velocities and top notch accuracy, especially when pushing heavy bullets. I think where it really shines is driving 300+ gr bullets in 44 and 45's, and 400+ gr in 475 and 500.