As far as the 38's hurting your chamber, contrary to popular belief, yes, if you shoot enough low pressure, or reduced 38's in a 357, they can, and definately will cut a nice ring in it right where the case mouths stop. If anybody doubts this, load up some 140-158 grain bullets in 38 cases with IMR-4227. Even fast burning powders will do it eventually, but that powder will burn a fairly deep ring usually within 100 rounds or less.
If you're wanting a good load for deer, try 158g Remington SP's with about 16g-17g of Lil' Gun, and CCI 550 primers. In that rifle, you should get somewhere around 1950-2100 fps with that combination, and it'll do excellent on deer up to 100 yards.