I have (Had) both calibers. I traded the 7/08 (6lbs scope and all) for a .22 hornet(Ruger with the heavey target bbl and brown lam stock). That guys 15 year old daughter killed a nice 4 x 4 first day out with that little gun. Then I went to the gun shop and picked up a box of 50 ,22 Hornets. They almost had to carry me out on a stretcher when they told me how much those little suckers are.The 7/08 was about six lbs scope and all, custom built. Loved it and it was what I carried if I was going to be moving a lot and covering ground. The 30/.06 may be the best, all around choice, but, what the heck, I would get the 7/08 because I ....already have an 06. PS. I was forced into buying the dies 6 boxes of different bullets, powder and brass for that little 22 Hornet. Just to keep from paying them $30.00 for 50 rnds loaded.