I think some of the calibers are ridiculous out of a handgun as well but many use them getting good accuracy so they apparently work.
You handle the recoil by hanging on. For the heavier hitters, muzzel brakes help a lot. When you compare "rifle" cartridges with "pistol" cartridges like the 500 S&W and the 460 S&W which are not considered ridiculous handgun cartridges, the recoil from the rifle cartridges isn't any worse. My routine for my 460 S&W off the bench is a weight lifter's glove on my right hand (to keep the skin on my thumb), a cushion under my right elbow, ear plugs and ear muffs; with that preparation it's not too bad to shoot (some disagree). Shooting off hand, the 460 S&W recoil isn't bad but the muzzel blast will clear the sinuses.
There have been clips floating around the internet of a guy shooting an Encore in 600 NE. That is something I never want to try.