Some of the reloading manuel's show the 22 250 about equal to the Swift,but there bullets will not withstand the full speed of the Swift. To get the full potential of the Swift,it needs a 26" barrel. The 220 will do 4300 to 4400 fps with a 40 gr. bullet at near max.loads,and some of the guy's are getting even more. Most of the 220's max load's are about 3 grs. more than the 22 250.
Yes they will burn a barrel out if you get it hot enough,but so will any of the other varmit caliber's.The Hornady varmiit load's were rated at 4250 fps. and they would do every bit of it through the chrono.I'm not sure if they would do well in a Handi though,because my 22 250 barrel shot loose after 70 rds. It took a .005 thick shim to bring it back to it's 1/2" groups with 40 gr. B.T.'s. Hope this helps. Digger