I've had good luck with 300-grain Laser Cast .452 bullets. A week ago I shot a nice four-point whitetail out of a .45 Colt - class wildcat using this bullet. It was a quartering-away shot. The bullet entered at the rear of the ribcage angling forward, smashed the liver and a lung tip, and exited. Both holes were about the same size. The organ cavity of the deer was a bucket of blood. The deer got maybe 50 - 60 yards. The bullet worked quite well.