I haven't shot a 22-250 in a Handi, and for some reason not too many report with theirs, maybe they aren't selling as many 22-250's as most other calibers
When I finally get one, I will for sure. It's a great round, and lots of reloading options.
However I can testify to the accuracy of the lil 204. It's a real performer, and probably the main competition for the 223's as being one of the most accurate rounds offered in a Handi IMO.
But as with both of these, factory ammo is a little expensive, and I would highly reccomend reloading.
-Aaron