I have a .45 LC Bisley 5 1/2" and a .45 LC Redhawk 5 1/2". I shoot both with the full spectrum of loads, up to 325 grain Garrets at 1325 fps. The Bisley is much more comfortable to me than my .44 Magnum 5 1/2 inch Blackhawk with the heaviest loads. The Redhawk is about equal to the Bisley in my mind. I build a .500 Linebaugh on a Redhawk 5 1/2" and am very happy with the results. I do think the lighter 255 grain cast .45 Colts and the 410 grain .500 Linebaughs are the way to go for casual practice, kept to 800 fps or so. I keep the heaviest loads for once a session sight confirmation, only one cylinder full, not 50 rounds or bust.