Well, if you're looking for a 'mouse gun' type carry gun. I'd do everything that I can to talk you OUT of a .22lr. There are so many larger caliber guns that are small enough for pocket carry that the .22 for this purpose is just wrong. While the .22 is certainly capable of dealing a lethal wound, the 9mm, .380, .32, .38 spl are all better choices in my opinion.
On the other hand, if you are looking for a 'plinker' type field gun. There are a number to choose from. S&W and Browning each make good ones and aren't the only ones. These generally aren't pocket small, but are pleasant to shoot and with good ammo, extremely accurate.