I have three 25 cal rifles. A Ruger#1 25-06, a Handi custom 257Roberts, A Rem 700SA in 25 Hunter (A 250 Sav Imp of sorts). In all of them I use 100gr bullets, one specific bullet for each rifle.
The 25-06 gets a 100gr TSX, the Roberts a 100gr Speer Hot core, the 25Hunter a 100gr Hornady Interlock FB. Each of these bullet perform best in the particular rifle.
Never had any reason to use a heavier bullet. 25-06 with TSX at 3430ft. The roberts at 3150 and the 25 Hunter at 3150. One shot kills is the rule with any of them. The 25 Hunter has shot the most game.