I have a old Lee mold that drops bulles weighting 250gr. The powders that I have used with good results are 20.0gr of H110, 19.6 gr of IMR-4227, and 17.5gr of AA#9. The AA#9 load is not near max, but accuracy started to fall off as I increased the powder.
I have a good 195gr mold, but the 250gr has become my do eveything bullet. It shoots well at low and high velocities.
At the range I used to shoot at I could shoot at the 10" gongs. These gongs were for rifle shooter and placed 300yd downrange. With just a little hold over (and a whole lot of practice) I got so I could get 1 or 2 hits out of 6 rounds