If your not familur with the big bores, take JJ's advice and try them out first before you buy them....
2 fridays ago, I placed an order for my first ever "large" bore rifle, CZ 550 in 416 rigby (american safari mag)
I NEVER thought of buying a big bore UNTIl I knew I was ready for its recoil. About a year ago, I bought my 375 h&h and been practicing with it for a while. I have fired close to 180-200 rounds of those remington 270 grs in the last 12 months. And even before I placed an order for the 416 rigby, 2 days before, I went and tried a few rounds in it (standing, not off the bench), i'll tell you what, it wasn't so bad the first and 2nd round, but at the 3rd, i was like "whoa.... yeh this is starting to hurt"
I knew that if I EVER wanted to get into the big bore world, I had to first learn to accept their recoil.
First recoil caliber I ever purchased was a 30-06,
then, 3 years later, 300 RUM (but the rifle along the scope weight more than 10 lbs), recoil was similar to 300 win mag in a lighter rifle. Then about 1 year ago, I bought my 375 h&h in winchester classic stainless, with the scope the rifle only weight bairly 9 lbs. Shooting them 270 gr at about 2700 fps, gives you about 39 ft-lbs of recoil.
Now, I "think" I might be ready for the rigby recoil. Not to plink, but to shoot about 3 to 4 rounds every time I go to the range for the first couple weeks.