as far as recoil goes.... recoil woun't break you nor hurt you, but like redhawk says, its there.
When I first got my 375 h&h, first day at the range, i purposly took only 5 rounds with me, I did not want to over do it and start developing any flinches..... 2nd time to the range, again I took only 5 rounds.... 3rd time (If i remember correctly), I took about 10 rounds.... but I stayed at 10 rounds for a few months.... When I was confortable, I started poping off 15-20 then thats it, i get tired after that and my groups start to open up a bit.
As far as recoil "figures" goes.... ever shot off a 165 grainer from a 30-06 ?, multiply that force X2 and thats your 375 h&h....I can't simply say "the h&h doesn't recoil a whole lot" but I will say that alot of women can get the hang of shooting them at full loads.
as far as holding the gun goes, its all about your physical structure......., so we rean't can't advice you on how to hold it, if your gun has open sights, try it out with the open sights and no scope, see how it feels for u.... then you can scope it as you wish