I didn't realize it till right now, but I failed to state that I was recommending the 280 WFN for 44 caliber. 300 grain is it's twin in 45 caliber, though for lower recoil, weights down to 250 gr are very accurate in both the 44 and 45.
I knew of one customer who had excellent long range results with a 400 gr LFN out of a FA Casull at speeds down to 800 fps and ranges out to 600 yards. This illustrates the importance of precision cylinder to barrel alignment, which is at it's best in FA revolvers because they are line bored. The other mass produced, and more affordable revolvers are not line bored, and are subject to misaligned cylinder throats. Sometimes in only one chamber, or up to all chambers. These throw a curve in any recommendation that I make, as I have to plan for the worst case guns. Thus I recommend lighter bullets for light loads. Yet, if your gun is well aligned, very heavy bullets will shoot like a lazer beam at long range with light loads.
Perhaps I should have clarified this in the beginning. If one is purchasing bullets to try out for performance, getting a hundred of several weights isn't a major cost factor. However, if purchasing an LBT mold, and a too heavy bullet is ordered, the cash outlay is prohibitive, and this is where I MUST season my recommendations heavily.
I have another factor which influences my opinions strongly, but may be meaningless to many customers. - I am a hunter, and have never been to a gun range in my 66 years. For all but a few of those years I could step out the back door and shoot any size gun I desired without causing neighbor problems. I set up a target to set the sights, normally, but not always, while probably a majority of my customers do most of their shooting at paper.
Through the years of my kind of shooting, I've found that plinking at all sorts of unknown ranges is the most practical teacher with a handgun, making it not only possible but quite certain that game down to cottontail rabbits are in extreme danger at ranges to 150 and 200 yards, and coyotes to 300 yards will normally have serious problems if I can get decent light on my revolver sights. But I'll always sneak up close as possible, if possible, prefering to take a 20 yard shot if I can. One can only learn to hit at all ranges by practice at all ranges, estimating the drop by 'feel'.
If this type of shooting appeals to you, you'll probably find, as I have that the bullet needs to be mosing at 1100 - 1200 fps, or faster, to make the mental range plotting easy. And once you have a precision load that is easy for your to work with, with enough power to be effective at long range, stick with it, and don't move the sights when playing with experimental loads. Let them hit where they will and just measure group sizes till your are content that this will be your new load, then set the sight for that load.