How close is "close"?
< 75 yards - sure, but if you want to take 100 yard shots I'd get ahold of some of the 220 gr. Buffalo Bore ammo if it will shoot in the gun. I'd also try to keep those corelocts away from big bones - at least on moose.
I really like more for moose 'cause I've had to do a couple of water retrievals, and those were shot with 338s. Outside 100 yards, pick another cartridge.