According to the yellow, 2000 Edition, Complete Reloading Manual For The T/C Contender... and assuming this is for hunting. Using Federal 210 Large Rifle Primers, and, Hodgdon H4227 starting load for a 300g Sierra JSP is 24.5 grains. With Winchester W296, and the same bullet, 27.4g to start. They say that this particular chambering does not lend it self to reduced loads and not to go bellow the listed charges. If you find that this is way more than necessary IMR Trailboss powder is great for the large capacity cases, my .444m does excellent with it.