In 42 years of hunting the NorthEast/New England, I've yet to take an animal over 150yds away from the muzzle - but only a few were that far, most coming well under 50yds. Some were so close, they could have been speared, instead. YMMV.
When I first started out, I went with what "everyone" used - the longer, heavier, more powerful rifles.
As I get older, I've gravitated to short/light - since I carry more than I shoot (at game), although I still prefer a rifle caliber of .35 or larger(even though I still have a few .30-06's). (I'm very recoil-tolerant)
"Short/light" means pistol cartridge to me, "over .35" means .44 Mag, and the combination is what I find I use for most everything these last few years - a Marlin M1894P(ported)LeverScout.
I can't argue with someone's decision to use a "thutty-thutty" the same way.