careful guy's, a good marksmen can hand throw a roundball in a 1" group at 50 yards. I think they call it baseball.
Rifle twist does matter. Projectile shape and lube does matter. Powder grade and charge does matter.
All of these factors do matter when one chooses to shoot a particular rifle at a particular range, for a particular purpose. Paper is different than Deer, Deer are different than Elk, and then there is Bear,,,50, 75 or 100 yards is each different than 1000 meters, and all targets can be hit by a marksmen with true BP traditonal arms.
The tacky grease of a Buffalo-ballet is different than a T/C maxi hunter,,a "spit-patch" is different than .10 ox-yoke wonder lube,sabots, bear grease, bees wax and snot, each affect the rifle differently. Pyrodex, T7, Goex, Swiss each affect in a different manner.
A marksmen knows the accuracy, capability and limits of his gun to his own ability. The hunter is a marksmen first.