I don't own a 500 mag, but when I was developing loads for my smith 44 mag, most told me the "bees knees" was 2400 and H-110. Well, I used both with several different bullet brands and never quite got the results that I thought I should. Then I came across a 44 mag post that suggested Vihtavuori N-110. Well, I loaded up some N-110 with Hornady 200 grain XTP's and my 629 DX Classic will put all 6 rounds in a 5" circle at 100 yards from a bench. That's from a rest of course and the gun is scoped. But that's the kind of performance I was looking for.
Now, I don't know if VV will do that for a 500 mag....but I load N-110 for my 357 180 grain XTP bullets as well and from my 3" smith I will hit the 12" plate at 50 yards 5 out of 7 shots....and that's standing free hand with a two hand grip.
FWIW
Dave