I shot a cow elk with my Ruger Hunter 45LC using Beartooth 300 grn LFNGC bullets, 21.5grn of H110, med crimp running at 1205fps. The shot was approx 55yds, setting along a abandoned road. She stepped out of the timber onto the road and I hit her high in the shoulder, broke both shoulder and spine. Dropped in her tracks. Good exit hole. This load is pretty stout in my Ruger Hunter w/a 2x6 scope for a little extra weight.
If it had been any farther I would have taken a double lung shot but I had been practicing and knew the pistol would do the trip.
Good luck on your hunt if you go.
Mike