My load as I described above works very good out to 200 yards. I get 3 inch groups. But you heard right about people getting worse groups when moving up in powder weight. But if they took the time, they can find a bullet that will give them good performance with more powder or pellets as I have. The only way to really find out, is to go to the range and do it. Just remember, what works for me, might not work as well for you. It is all trial and error.
I have not tried the 300 gr. sabots, because the scope is set up for the 250 gr. weight bullets.