There is no simple answer - yes it is best or no it is not best. Gray Beard covered it pretty well. Personally - in Revolver loads I stick with the recommended OAL as much as possible. In hunting loads I use the same criteria that Gray Beard does. In a hunting load, accuracy is not the only concern; reliable functioning is very important too. Get cartridges too long and they hang up in the action. Too short and you are cutting down on the velocities possible with it. In the target/varmint guns I try to start at the lands, if possible. Again this may be dictated by the functioning of the action or the throat maybe too long to seat the bullet in to the lands. If I can not start at the lands, then I back off as little as possible, and still cycle through the gun and enough of the bullet in the neck. But generally make the cartridge as long as I dare. I pick a likely powder and bullet. I vary the powder charges starting with the lowest recommended and slowly work my way up to maximum. Knowing that maximum in the book may be too high if I am into the lands already. I then vary the seating depth if I do not get satisfactory results. What is satisfactory to one is not to another. I used to think I had to get sub 1/2 MOA with five shots on every varmint gun I own. When I had one varmint gun that was possible, I do not have the time to work up a great load for every gun I own. Like Gray Beard, If I can get it into 3/4" constantly I am good. A bench rest shooter is concerned about getting every ounce of accuracy they can out of one gun. They spend the time to develop the perfect load. I just do not have the time. I have several "varmint" guns and it takes considerable time to work up the perfect load. I like doing that, it is kind of therapeutic to me, just do not have the time to do it anymore, there are way too many variables to work out.