Several years ago, I experimented with light weight 44 cal bullets in my Ruger carbine. My findings were interesting. I was interested in increasing velocity by using 180 to 200 gr bullets. These lighter bullets gave very poor accuracy with 100yd groups around 4 to 5 inches. Heavier bullets, 240, 250, 270, and 300 all gave 1 to 2 inch groups. The experiment ended and I routinely use 240 or 270 gr bullets over H110 or Wiin296. I never had problems with the 300gr as long as they are seated to the recommended length.
best, nrb