Hey Dale...
For shot placement with a firearm.... I almost always go for the boiler room and have yet to lose a deer. Only on a very rare occasion will I even consider anything different. In fact, only two of my deer were ever harvested without going for the vitals. One was a close range neck shot with a .44mag revolver. This doe dropped in her tracks. The other was a cull buck, spine shot from a tree stand with a bow. Although successful, this was one shot I would like to take back if I only could. This was a BAD choice on my part.
I try to think in 3D when drawing down on game. I think to myself... where's the heart and how do I get there? As ethical hunters, we owe it to the game we're after to delivery an accurate shot for a humane harvest. Equipment set up is only part of it. Your rifle is a true shooter, no doubt about that. The rest is up to you.
I'll be leaving in about a half hour for an evening hunt on a new area we have access to. Saw good numbers yesterday, but nothing in range of the .50 smoke pole. With the winds we're having today, and with all the hammering they've faced through rifle season, they probably won't be moving until close to sun down. But you can't fill the freezer while sitting on the couch...
Good luck to ya, buddy!!! Stay safe and I hope you enjoy a successful hunt!!!
Dan