"Wouldn't even try to shoot a deer with less than a 295 gr PB, just not enough lead for the size of the HP (the aerotips are just HP with the plastic tip shoved in it)"
People once tried telling me that. I took a great sized doe with the 45cal 225g powerbelt aerotip with 80g fffg triple 7 @ 80 yards.
I can pee farther than the distance she traveled after being hit.
If you want pass through with a powerbelt, Go the the lungs. I prefer the shoulder/heart shot as if bleeds them out quick and leaves an easy to follow trail.
Also forgot to mention that the Aerotip helps control over expanding of the bullet.