Heck didn't think I was raising a red flag here on loads. I mean a 335gr LFNGC at 1050fps is hardly a hot load certainly under 20K psi and probably under 18K. I have run a few in my Smith Mountain gun but that is not what that gun is for unless there are big bears to worry about. I suppose it would be better to define what Vaquero we are shooting but then I guess I did that to, and it is unreasonable for some to know the Bisley Vaquero was discontinued several years ago and has only produced in the older large frame configuration that handles 30k PSI loads or so as published in dozens of reloading manuals and articles.
The point is that for deer, whitetail or mule deer, any 45 colt cast bullet load from 255gr up is plenty. What is more important is to learn to hit well with them.
Lloyd the Matado is a intreging gun that I have yet to rap my mitts around in any shop. It was produced, according to Ruger, for the mounted cowboy action shooters who shoot blanks from horse back! That is why it is stainless steel (so they can clean their guns in the dish washer!) and 45 colt (because it is the only cartridge allowed, they all shoot the same blanks from the same box to level the field). I think it would be a pretty cool small gun to tinker with and shoot a lot. I wouldn't be tempted to hunt big game with it but it's little size might be tempting to carry CCW with! So being limited to lighter shorter bullets would not bother me. Heck a lot can be said for a 255gr or a 280gr WFN at moderate distances! Heck I might special order one but the wife watches the credit card balances too close! But I will agree that both guns are begging for a 44 special factory model, and a blued matado, better yet a Bisley griped, round butted blued version!