I looked in my Lee 2nd manual, it lists IMR 4227 for the 35 Whelen, 200gr jacketed, 32.4gr start, 36.5gr max, but at a velocity of only 2290fps, they also list IMR4064 at a max velocity of 2700fps, so the 4227 doesn't sound like a good choice in that chambering to me.
Lee lists IMR4227 for the 175gr 7RemMag, 31.4gr start, 35.5gr max at 2240fps, but here again, it's the slowest of the bunch of powders, IMR7828's max load is 2910fps.
They list it for the 110gr jacketed 308 Win, 28.2 start, 32gr max at 2835fps, but again, a poor choice for velocity, top velocity for that weight bullet is 3300fps. 150gr jacketed bullets get 2260fps with a max load of 26gr, bottom of the pack again. I don't understand this, but the 180gr bullet max is 27gr
at 2110fps, one grain more than the 150gr jacketed.
You can use it, but it's far from ideal.
Tim