I've used the 220 gr. Hornady quite a bit in my 12" .375 JDJ @~ 2200 fps, which is faster than it will run out of a 14' .375 Win., by perhaps 150- 200 fps. It has worked very well for me on deer sized game, and although I don't own a .375 Win., it's the bullet I would try first in that cartridge.