It goes without saying, that all barrels don't perform alike, but the E R Shaw barrel I had didn't seem to care what I put in it.
This was one of the first cartridges I ever reloaded, and some of my combinations weren't all that good.
The rifle still shot accurately, and I learned a great deal about pressure, and velocity's effect on group size.
I guess what I'm getting at is the .22-250 is a very forgiving cartridge that can be lots of fun to experiment with.