Yes, you sure can, if it's large enough to fit your revolver. Since it doesn't have a crimp groove, seat it deep enough so you can crimp over the ogive so the bullet won't move forward from recoil. If you have fixed sights, and perhaps even with adjustable set high as they will go, the bullet will probably strike way below the sights, especially if fired up pretty hot. This because of the lightweight bullet not creating enough recoil and recoil time to raise the gun up for proper impact, before it leaves the muzzle.