For CAS, a medium hard bullet alloy w/about any commercial lube is ideal. ALWAYS size your bullets to at least 0.001-inch OVER barrel groove diameter. If you're shooting super-hot magnum loads, you may need a special alloy and a great lube.
Leading is generally caused by one or more of several factors:
-- Bullet diameter too small (leading near the cylinder end of barrel)
-- Bullet alloy way too hard. (leading near the cylinder end of barrel)
-- Bullet alloy too soft, with velocity over 1,000 fps (too fast for CAS)
-- Lube failure (rare, nowadays IMO, shows leading near the muzzle)
-- Leading in chamber throats: Cylinder throats too small.
Is your Ruger leading at the muzzle, or back closer to the cylinder-end of the barrel? If it's the muzzle, you probably have 'lube failure'.
And Pigeonroost Slim is correct: If your chamber throats are too small, get 'em reamed ASAP. Chances are good that your Ruger groove diameter is .4515 +/- 0.0005-inches. So a medium hard bullet of .452 diameter should not cause leading up to 1,000 fps. If your groove diameter is larger than .452, you need a soft bullet alloy and a .454 bullet diameter.
If your chamber throats are smaller in diameter than the groove diameter of your bullet, you're gonna lead the barrel. I've heard-tell that Ruger will fix your throats at no charge (except you pay freight, I think). --CC