First, Fackler is not a big fan of " one shot syop" statistics. He is the guy on the other side of the argument. Some people argue that the Strauseburg tests never took place. That could be true. Maybe they are just an urban myth. But the thing that I don't like about the whole series of tests, if they did take place, is that the goats were shot broadside through the lungs. I have shat quite a few slaughter hogs with a .22 target pistol, all of them in the head. They are all very very dead. Does that make a one shot stopper out of a .22? Absolutely not!
In reality, you must ask yourself a question; would I let someone shoot at me standing still? OF course not! Neither would any one that you might be likely to shoot in a defensive setting. The correlation between hunting and self defense is almost 100%. The hunter and the individual who is defending his own life both want the same thing; dead meat on the ground. The hunter so he doesn't have to track a wounded animal, and the citizen because he doesn't want to be injured by a wounded "animal".
When you are hunting, you will seldom be presented with a picture perfect broadside lung shot, or a head shot. It is even less likely in a self defense scenario. Penetration trumps everything except accuracy. Period. And don't believe me, go out and kill something, like a deer or an elk. A little bit of real life experience and you will know more than 99% of "keyboard commandos " and gun rag shootists.