I believe current Indiana regs are:
"Handguns, other than muzzleloading, must have a barrel at least 4 inches long and must fire a bullet of .243-inch diameter or larger. The handgun cartridge case, without the bullet, must be at least 1.16 inches long.
Full metal-jacketed bullets are not permitted.
Handguns are not permitted on any military areas.
Some types of handgun cartridges legal for deer hunting include:
.357 Magnum
.41 Magnum
.44 Magnum
.44 Special
.45 Colt
.45 Long Colt
.45 Winchester Magnum
.35 Remington
.357 Herrett.
Some illegal handgun cartridges for deer hunting are 38 Special, 38 Smith and Wesson, 38 Colt New Police, 38/200, 38 Long Colt, 38 Super, 38 ACP, 38 Colt Auto, 45 ACP, 45 Automatic and 45 Auto Rim. All 25/20, 32/20 and 30 carbine ammunition is prohibited also."
That opens the door to lots of lower recoil, high performance rounds. The Remington 6.8 SPC seems like a good one. A good muzzlebreak helps.