Your a right on with Unique. 8gr for a light load at about 800fps, 8.5 for factry duplication at about 850fps and 9gr gets about 900fps or a little better. That's where I would stop with that light frame. Don't be fooled by the latest magazine article, inside 50 yards that last load will handle about 98% of anything you might ever try. Sorry I can't help with Titegroup, just haven't tried it yet. Haven't run out of Unique and Bullseye. From my studies so far, I believe you will be able to get to about 800fps with that 250gr bullet, but you will probably run into pressure problems after that. To gain any more speed with Titegroup you will have to drop down in bullet weight. BOL