Dand, I've been using AA3100 since its introduction. It has performed superbly in my rifles. Nobady called it pretty close on best uses although he didn't mention that the more overbore the cartridge, the better the application. It is my favorite powder for the 280 Rem, 270 Win, and 243 Win. The first load I ever fired in my 300 H&H M721 tried to stack Hornady 180 gr bullets on top of each other, so I never tried a second load. I wouldn't hesitate to use it in the '06 if I wasn't trying to squeeze all the fps out of the load I could get. The burning rates and applications are much closer to the 4831's than you think.